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KMID : 0350519920450031027
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Journal of Catholic Medical College
1992 Volume.45 No. 3 p.1027 ~ p.1034
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Cell Mediated Immunity in Asthma Patient with Dust Mite Allergy
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Abstract
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The allergic disease is characterized by hyperreactivity of IgE-producing B cells against allergens. A high serum IgE level has been noted in the case of T cell dysfunction, so that it appears to be an association between allergic disease and
cell
mediated immune deficiency. This study was performed to elucidate the role of cell mediated immunity in developing dust mite asthma and its influence on immunotherapy.
Lymphocyte stimulated responses and Interleukin-2 production to mitogen(PHA, Con-A, PWM) or allergen (D, pteronyssinus, D. Farinae) were measured in 15 normal children, 15 newly diagnosed dust mite asthma(new patients) and 15 dust mite asthma on
immunotherapy for 18 months (immunotherapy patients).
@ES The results were as follows
@EN 1. Percent inhibitions of the prepared D pteronyssinus and D. farinae were 90% and 88% in RAST(Pharmacia Co., Sweden) inhibition test.
2. Lymphocyte stimulated responses to PHA or Con-A stimulation in norma children(121.0*31.6, 97.8*24.1) were significantly increased as compared to new patients(79.2*18.7, 46.9*12.1) and immunotherapy patients(82.3*21.1, 57.3*16.2), (P<0.001).
Between the patients, immunotherapy patients(57.3*16.2) showed significantly increased in Con A response as compared to new patients(46.9*12.1), (P<0.05). But there was no difference between normal children(31.7*8.9) and patients(28.6*7.1,
27.2*8.4) in
response to PWM stimulation.
3. Lymphocyte stimulated reponses to D, pteronyssinus or D. farinae in new patients(9.8*2.1, 10.4*2.7) were significantly increased as compared to normal children(3.3*0.8, 3.6*0.9) and immunotherapy patients(5.3*1.0, 6.2*1.1), (P<0.001).
4. There was no difference among normal chidren(23.8*3.7AU/ml), new patients(23.1*4.0 AU/ml) and immunotherapy patients(22.9*3.6AU/ml) in the production of Interleukin-2 to mitogen(PHA). But Interleukin-2 production to D. Pteronyssinus in new
patients(28.6*5.2AU/ml) were significantly increased as compared to normal children(23.0*4.3AU/ml) and immunotherapy patients(24.3*4.9AU/ml), (P<0.01).
In conclusion, new patients showed a decreased T cell, function and increased helper T cell reactivity to allergen. Immunotherapy restored the deficient T cell, probably suppressor T cell, function and diminished the helper T cell activity to
allergen.
This suggests that cell mediated immunity is involved in the pathogenesis of allergic disease and the immune mechanisms of immunotherapy.
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KEYWORD
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